Vaccine and prophylaxis

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Yellow Fever Vaccination

Vaccination schedule

The vaccination comprises a single subcutaneous injection administered from the age of 9 months onwards. The vaccine confers at least 10 years of immunity in nearly 100% of recipients.

Yellow fever vaccination certificate is an international vaccine certificate required for entry into countries. Although immunity following vaccinations has been shown to be long lasting, the International Health Regulation (2005) requires re-vaccination at 10-year intervals in order to retain a valid certificate. Travellers should remember that the certificate is valid only 10 days after the primary injection and the first dose of vaccine takes 10 days to provide good protection therefore adequate time should be allowed for vaccination before departure.

Recommendations

Yellow fever occurs only in parts of Africa, Central and South America. Travellers visiting the endemic zone should consider vaccination and carry the vaccine certificate. Since the actual area of the endemic zone varies from time to time, travellers should take note of this and consult their doctors for opinions.

Adverse reactions

10-30% of recipients will experience mild headache, low-grade fever and myalgia after immunisation. Immediate allergic reaction have been reported but is rare.

Contraindications

The contraindications for yellow fever vaccination include:

  • Having a febrile illness.

  • Person known to have hypersensitivity reactions to neomycin, polymyxin and egg.

  • Pregnant women.

  • Infants under six months old.

  • On immunosuppressive treatment or having radiotherapy.

  • Suffering from immunosuppressive diseases such as lymphoma, thymoma, leukaemia, Hodgkin' s disease and hypogammaglobulinaemia.

  • If other live vaccines are required, 4 weeks of interval time are needed between injections.

  • Safety is uncertain in both symptomatic or asymptomatic HIV positive individuals.
 

Last revision date: 9 September 2013