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Primary vaccination consists of a series of three shots with the first
and second dose given one month apart, and the third dose at the sixth
month. Booster doses are given 6-12 months later. The schedule is for
persons of age 18 years or above. Data is insufficient for drawing up
recommendation for those below age of 18.
No country requires a vaccination certificate against plague as a condition of entry. The vaccine is normally recommended only for persons with a very high risk of exposure, for instance laboratory workers and field workers working in plague epizootic areas. Travellers to countries reporting plague cases rarely need vaccination, unless the risk of exposure is very high. Even then, a short course of preventive antibiotics with doxycycline during exposure periods is often preferred.
Adverse reactions are quite common, including mild pain, redness, induration
at injection sites. More severe headache, tiredness and fever often occur
with repeated injections.
Last revision date: 10 October 2012